During standard lipoprotein electrophoresis, which lipoprotein is typically seen remaining at the origin due to its large size?

• A. HDL
• B. Chylomicrons
• C. LDL
• D. VLDL

Answer: (B)

Mobility in lipoprotein electrophoresis mainly follows particle size and charge. Chylomicrons are the largest lipoproteins, carrying a lot of triglycerides, and their size is so large that they barely migrate through the gel matrix under standard conditions. Because of that, they remain at the origin. The smaller lipoproteins move away from the origin: HDL is the smallest and migrates the farthest, while LDL and VLDL are intermediate. So the lipoprotein that stays at the origin is the chylomicrons.