Hormone replacement does not inhibit bone resorption in osteoporotic patients.

• A. True
• B. False
• C. Not enough information
• D. Sometimes

Answer: (B)

Estrogen replacement reduces bone resorption. In osteoporosis, loss of estrogen removes a braking effect on osteoclasts, leading to increased bone breakdown. Estrogen helps by directly inhibiting osteoclast formation and activity, promoting osteoclast apoptosis, and shifting cytokine signaling to decrease RANKL and increase osteoprotegerin (OPG). This collectively slows resorption and helps preserve bone density, lowering fracture risk. Because of this inhibitory effect on bone resorption, the statement is not correct.