Increased levels of apo A-I are associated with increased risk of CAD. True or False?

• A. True
• B. False
• C. Not related
• D. Unknown

Answer: (B)

ApoA-I is the main protein in HDL, the so‑called “good” cholesterol, and HDL plays a key role in reverse cholesterol transport. It gathers cholesterol from arterial wall macrophages and tissues and ferries it to the liver for excretion, helping to limit plaque buildup. Higher levels of ApoA-I generally mean more functional HDL particles and better cholesterol removal, along with anti-inflammatory and antioxidant effects that protect against atherosclerosis. Because of this protective mechanism, increased ApoA-I is linked to a lower, not higher, risk of coronary artery disease. So the statement is not correct.