LD isoenzyme analysis helps distinguish damage to which tissues?

Prepare for the Bishop Clinical Chemistry Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

LD isoenzyme analysis helps distinguish damage to which tissues?

Explanation:
Lactate dehydrogenase comes in several isoenzymes, each with a characteristic distribution in different tissues. When tissue is damaged, the corresponding isoenzymes spill into the bloodstream, and the pattern of which isoenzymes are elevated points to the tissue of origin. The heart has a prominent LDH-1 form, while the liver and skeletal muscle show higher LDH-5 activity, and the lungs favor LDH-3. Because of these patterns, LD isoenzyme analysis helps distinguish damage to heart, liver, and skeletal muscle most clearly.

Lactate dehydrogenase comes in several isoenzymes, each with a characteristic distribution in different tissues. When tissue is damaged, the corresponding isoenzymes spill into the bloodstream, and the pattern of which isoenzymes are elevated points to the tissue of origin. The heart has a prominent LDH-1 form, while the liver and skeletal muscle show higher LDH-5 activity, and the lungs favor LDH-3. Because of these patterns, LD isoenzyme analysis helps distinguish damage to heart, liver, and skeletal muscle most clearly.

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