Skin, _____, and kidneys are involved in the production of the active metabolite of vitamin D.

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Multiple Choice

Skin, _____, and kidneys are involved in the production of the active metabolite of vitamin D.

Explanation:
Vitamin D activation requires three steps involving skin, liver, and kidney. UV exposure converts 7-dehydrocholesterol in the skin to vitamin D3. The liver then performs 25-hydroxylation to form 25-hydroxyvitamin D, which is the main circulating form. Finally, the kidneys carry out 1α-hydroxylation to produce 1,25-dihydroxyvitamin D, the biologically active metabolite. The missing tissue is the liver, because it carries out that essential first hydroxylation step before the kidney completes activation. The other organs listed do not participate in this activation sequence.

Vitamin D activation requires three steps involving skin, liver, and kidney. UV exposure converts 7-dehydrocholesterol in the skin to vitamin D3. The liver then performs 25-hydroxylation to form 25-hydroxyvitamin D, which is the main circulating form. Finally, the kidneys carry out 1α-hydroxylation to produce 1,25-dihydroxyvitamin D, the biologically active metabolite. The missing tissue is the liver, because it carries out that essential first hydroxylation step before the kidney completes activation. The other organs listed do not participate in this activation sequence.

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