Teriparatide is the only FDA-approved drug for osteoporosis that directly stimulates bone formation.

• A. True
• B. False
• C. Not sure
• D. Both

Answer: (A)

Teriparatide is an anabolic osteoporosis therapy that works by intermittently stimulating osteoblast activity to build new bone, making it a strong option for increasing bone formation. However, it is not the only FDA-approved drug with this effect. Abaloparatide, another PTH-related peptide analog, also directly stimulates bone formation by activating osteoblasts. Additionally, romosozumab, a sclerostin inhibitor, enhances bone formation (especially early on) while also reducing bone resorption, giving it a net anabolic effect. In contrast, many other osteoporosis drugs, like bisphosphonates, primarily inhibit bone resorption rather than stimulate formation.

Therefore, the statement is not accurate; there are other FDA-approved agents that directly promote bone formation.